FBXL2

Across TCGA cell cohorts, FBXL2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL2-associated genes across cancer lineages are OR1L3, BEND2, and TECRL. Each is linked with FBXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL2-to-partner and partner-to-FBXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by FBXL2-low versus FBXL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL2→partner) and Y-score (partner→FBXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1L3 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	BEND2 →	+0.032	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L3 by FBXL2 expression — LARGE_INTESTINE

Explore this box plot interactively →