FBXL19

Across TCGA patient cohorts, FBXL19 mutation is significantly associated with the RNA expression of many other genes, with 564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL19-associated genes across cancer lineages are C2orf69P4, RPL12P40, and ATP6V0CP2. Each is linked with FBXL19 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL19-to-partner and partner-to-FBXL19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf69P4 grouped by FBXL19-low versus FBXL19-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL19→partner) and Y-score (partner→FBXL19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C2orf69P4 →	+0.067	+6.419	<.001	<.001	3	3
CESC	RPL12P40 →	+0.045	+4.342	<.001	.007	3	2
CESC	ATP6V0CP2 →	+0.154	+3.922	<.001	.003	3	2
BRCA	RNU7-81P →	+1.003	+5.711	<.001	.001	3	2
UCEC	LETM1 →	+0.418	+2.627	.002	<.001	3	2
UCEC	JMJD6 →	+0.382	+2.087	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 564 associations by consensus.

C2orf69P4 by FBXL19 expression — COAD

Explore this box plot interactively →