FBXL19

Across TCGA patient cohorts, FBXL19 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL19-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with FBXL19 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL19-to-partner and partner-to-FBXL19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FBXL19-low versus FBXL19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL19→partner) and Y-score (partner→FBXL19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.146	+2.472	.009	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.724	+2.479	.002	.010	3	2
UCEC	14-3-3_beta →	-0.081	-2.295	.045	.033	3	1
UCEC	A-Raf_pS299 →	-0.138	-2.459	.004	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-1.893	.002	.016	3	1
UCEC	JNK2 →	+0.212	+2.834	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by FBXL19 expression — UCEC

Explore this box plot interactively →