FBXL19

Across TCGA cell cohorts, FBXL19 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL19-associated genes across cancer lineages are ZP2, IFNA6, and SLC22A6. Each is linked with FBXL19 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL19-to-partner and partner-to-FBXL19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZP2 grouped by FBXL19-low versus FBXL19-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL19→partner) and Y-score (partner→FBXL19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZP2 →	+0.156	+3.678	<.001	.009	3	2
BREAST	IFNA6 →	+0.060	+3.781	.001	.009	3	1
BREAST	SLC22A6 →	+0.003	+3.781	<.001	.009	3	1
BREAST	TMEM233 →	+0.053	+3.232	.001	.006	3	1
CNS	DEFA1 →	+0.375	+3.874	.001	.006	3	1
BLOOD_Leukemia	CRX →	+0.031	+4.772	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ZP2 by FBXL19 expression — LARGE_INTESTINE

Explore this box plot interactively →