FBXL16

Across TCGA patient cohorts, FBXL16 mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL16-associated genes across cancer lineages are MLLT10P2, RNU6-416P, and RN7SL513P. Each is linked with FBXL16 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL16-to-partner and partner-to-FBXL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT10P2 grouped by FBXL16-low versus FBXL16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL16→partner) and Y-score (partner→FBXL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLLT10P2 →	+0.138	+2.657	<.001	.006	3	3
CESC	RNU6-416P →	+0.149	+4.569	<.001	.005	3	2
UCEC	RN7SL513P →	+0.329	+2.747	<.001	<.001	3	2
UCEC	MIR7976 →	+0.544	+2.716	<.001	.001	3	2
UCEC	SNHG30 →	+0.712	+3.191	<.001	.009	3	2
UCEC	TRIM73 →	+0.159	+3.928	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

MLLT10P2 by FBXL16 expression — UCEC

Explore this box plot interactively →