FBXL16

Across TCGA patient cohorts, FBXL16 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL16-associated genes across cancer lineages are Eosinophils, Endothelial cells, and Astrocytes. Each is linked with FBXL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL16-to-partner and partner-to-FBXL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Eosinophils grouped by FBXL16-low versus FBXL16-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL16→partner) and Y-score (partner→FBXL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Eosinophils →	+0.034	+2.910	.001	.012	3	1
UCEC	Endothelial cells →	-0.043	-2.764	.009	.003	3	1
UCEC	Astrocytes →	-0.040	-2.920	.047	.024	3	1
UCEC	MEP →	+0.024	+1.595	.046	.045	3	1
UCEC	Th1 cells →	+0.089	+2.467	.029	.011	3	1
UCEC	Melanocytes →	-0.010	-2.061	.027	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Eosinophils by FBXL16 expression — LUSC

Explore this box plot interactively →