FBXL16

Across TCGA cell cohorts, FBXL16 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL16-associated genes across cancer lineages are OR10T2, SLC5A4, and RIMS4. Each is linked with FBXL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL16-to-partner and partner-to-FBXL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by FBXL16-low versus FBXL16-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL16→partner) and Y-score (partner→FBXL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	2
BLOOD_Leukemia	SLC5A4 →	+0.310	+4.471	<.001	.001	3	1
BLOOD_Leukemia	RIMS4 →	+0.216	+3.675	.002	.003	3	1
BLOOD_Leukemia	SLC32A1 →	+0.990	+3.223	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.047	+2.982	.004	.007	3	1
BLOOD_Leukemia	PHOX2B →	+0.022	+4.687	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

OR10T2 by FBXL16 expression — BREAST

Explore this box plot interactively →