FBXL15

Across TCGA pan-cancer cohorts, FBXL15 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FBXL15 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXL15 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXL15 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where FBXL15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.460	0.963	.007	11	view →
CCRCC	DFS	Quartile	All	0.942	0.681	.006	7	view →
LSCC	DFS	Tertile	All	0.904	1.000	.014	6	view →
HNSC	DFS	Median	IV	1.000	0.920	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FBXL15–PDAC (OS)

Open the PDAC breakdown →