FBXL14

Across TCGA cell cohorts, FBXL14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,256 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL14-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Nucleosome disassembly, and Positive regulation of mitotic cytokinesis. Each is linked with FBXL14 in more than 12 cancer types. Because this analysis shows association rather than direction, both FBXL14-to-partner and partner-to-FBXL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by FBXL14-low versus FBXL14-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL14→partner) and Y-score (partner→FBXL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	mRNA alternative polyadenylation →	+0.112	+1.493	<.001	<.001	3	13
BONE	Nucleosome disassembly →	+0.171	+1.304	<.001	<.001	3	12
BREAST	Positive regulation of mitotic cytokinesis →	+0.142	+1.008	.001	<.001	3	12
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.068	+1.065	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.177	+1.327	<.001	<.001	3	12
OVARY	Regulation of chromatin organization →	+0.078	+0.720	<.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,256 associations by consensus.

mRNA alternative polyadenylation by FBXL14 expression — BONE

Explore this box plot interactively →