FBXL14

Across TCGA cell cohorts, FBXL14 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL14-associated genes across cancer lineages are ACSM6, CFHR2, and AMELY. Each is linked with FBXL14 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL14-to-partner and partner-to-FBXL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM6 grouped by FBXL14-low versus FBXL14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL14→partner) and Y-score (partner→FBXL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
LARGE_INTESTINE	AMELY →	+0.036	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACSM6 by FBXL14 expression — LARGE_INTESTINE

Explore this box plot interactively →