FBXL12

Across TCGA pan-cancer cohorts, FBXL12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXL12 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXL12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXL12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where FBXL12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.144	0.533	.004	24	view →
CCRCC	DFS	Median	All	1.000	0.340	.014	15	view →
LSCC	DFS	Quartile	III,IV	0.619	1.000	.025	3	view →
LUAD	DFS	Median	All	0.820	0.391	.010	2	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.888	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXL12–PDAC (DFS)

Open the PDAC breakdown →