FBRS

Across TCGA pan-cancer cohorts, FBRS Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBRS data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBRS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBRS expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

HNSC, LIHC, and COAD are the cancer types where FBRS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
COAD	DFS	Median	II,III,IV	1.000	0.649	.030	5	view →
SKCM	OS	Median	III,IV	0.311	0.707	.022	3	view →
UCEC	DFS	Median	All	0.914	0.628	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBRS–HNSC (DFS)

Open the HNSC breakdown →