FBRS

Across TCGA pan-cancer cohorts, FBRS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBRS data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FBRS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBRS expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where FBRS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.982	0.345	.001	20	view →
HNSC	OS	Tertile	All	0.259	1.000	.021	17	view →
PDAC	OS	Median	III,IV	0.440	0.977	.021	8	view →
GBM	DFS	Median	All	0.648	0.843	.020	2	view →
CCRCC	OS	Median	All	0.730	1.000	.027	2	view →
LSCC	DFS	Median	III,IV	0.630	0.988	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBRS–LUAD (DFS)

Open the LUAD breakdown →