FBRS

Across TCGA patient cohorts, FBRS mutation is significantly associated with the RNA expression of many other genes, with 2,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBRS-associated genes across cancer lineages are MIR194-1, RPS27L, and NCR1. Each is linked with FBRS in more than 1 cancer types. Because this analysis shows association rather than direction, both FBRS-to-partner and partner-to-FBRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR194-1 grouped by FBRS-low versus FBRS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBRS→partner) and Y-score (partner→FBRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR194-1 →	+0.617	+2.505	<.001	.005	3	2
UCEC	RPS27L →	+0.630	+2.413	<.001	<.001	3	2
COAD	NCR1 →	+0.382	+3.375	<.001	.005	3	2
COAD	XRCC6 →	+0.474	+3.362	.001	.005	3	2
UCEC	YRDC →	+0.415	+1.931	.002	.009	3	2
UCEC	PTMAP9 →	+0.829	+2.346	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,393 associations by consensus.

MIR194-1 by FBRS expression — COAD

Explore this box plot interactively →