FBRS

Across TCGA patient cohorts, FBRS mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBRS-associated genes across cancer lineages are ATM, eIF4E, and GAPDH. Each is linked with FBRS in more than 2 cancer types. Because this analysis shows association rather than direction, both FBRS-to-partner and partner-to-FBRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FBRS-low versus FBRS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBRS→partner) and Y-score (partner→FBRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.428	-2.087	.013	.005	3	3
UCEC	eIF4E →	+0.183	+2.700	.024	.006	3	2
UCEC	GAPDH →	+0.408	+1.700	.047	.042	3	2
UCEC	HER3_pY1289 →	+0.074	+1.704	.024	.013	3	2
UCEC	MEK1 →	+0.397	+3.906	.004	<.001	3	2
UCEC	mTOR_pS2448 →	-0.164	-2.095	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by FBRS expression — UCEC

Explore this box plot interactively →