FBRS

Across TCGA cell cohorts, FBRS mutation is significantly associated with the RNA expression of many other genes, with 820 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBRS-associated genes across cancer lineages are MPC1L, MOGAT3, and OR4F21. Each is linked with FBRS in more than 2 cancer types. Because this analysis shows association rather than direction, both FBRS-to-partner and partner-to-FBRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPC1L grouped by FBRS-low versus FBRS-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBRS→partner) and Y-score (partner→FBRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	3
CNS	MOGAT3 →	+0.043	+3.774	<.001	.008	3	2
LARGE_INTESTINE	OR4F21 →	+0.112	+2.041	<.001	.007	3	2
LARGE_INTESTINE	ANKRD63 →	+0.220	+2.793	<.001	<.001	3	2
KIDNEY	HNRNPCL3 →	+0.057	+4.954	<.001	<.001	3	1
URINARY_TRACT	CES5A →	+0.016	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 820 associations by consensus.

MPC1L by FBRS expression — URINARY_TRACT

Explore this box plot interactively →