FBP2

Across TCGA patient cohorts, FBP2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBP2-associated genes across cancer lineages are ACC1, Heregulin, and JNK2. Each is linked with FBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBP2-to-partner and partner-to-FBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by FBP2-low versus FBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBP2→partner) and Y-score (partner→FBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.346	+2.115	.029	.019	3	1
UCEC	Heregulin →	-0.107	-2.584	.046	.010	3	1
UCEC	JNK2 →	+0.199	+3.179	.022	.010	3	1
UCEC	MEK1 →	+0.390	+3.700	.014	.001	3	1
UCEC	Annexin-1 →	+0.588	+2.189	.010	.034	3	1
UCEC	Shc_pY317 →	-0.246	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ACC1 by FBP2 expression — UCEC

Explore this box plot interactively →