FBN3

Across TCGA pan-cancer cohorts, FBN3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBN3 data layer compared with 27 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBN3 expression acts as an unfavorable survival marker.

PDAC, COAD, and UCEC are the cancer types where FBN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.288	0.547	<.001	89	view →
COAD	DFS	Quartile	III,IV	0.675	1.000	.018	60	view →
UCEC	OS	Quartile	III,IV	0.213	1.000	.013	28	view →
LSCC	OS	Tertile	III,IV	0.430	1.000	.034	3	view →
GBM	DFS	Median	All	0.730	0.822	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBN3–PDAC (DFS)

Open the PDAC breakdown →