FBN1

Across TCGA pan-cancer cohorts, FBN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FBN1 data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBN1 expression acts as an unfavorable survival marker.

PDAC, LSCC, and CCRCC are the cancer types where FBN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.659	0.841	<.001	67	view →
LSCC	DFS	Median	All	0.559	0.840	<.001	46	view →
CCRCC	DFS	Median	All	0.621	0.855	.005	31	view →
COAD	DFS	Quartile	III,IV	0.739	1.000	.046	6	view →
GBM	OS	Tertile	All	0.762	0.912	.009	6	view →
UCEC	DFS	Quartile	II,III,IV	0.364	0.872	.044	4	view →
HNSC	DFS	Median	All	0.554	0.701	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FBN1–PDAC (DFS)

Open the PDAC breakdown →