FBLN7

Across TCGA patient cohorts, FBLN7 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBLN7-associated genes across cancer lineages are eIF4E, mTOR_pS2448, and PCNA. Each is linked with FBLN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBLN7-to-partner and partner-to-FBLN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FBLN7-low versus FBLN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN7→partner) and Y-score (partner→FBLN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+3.335	.019	.005	3	2
UCEC	mTOR_pS2448 →	-0.156	-1.678	.006	.023	3	2
UCEC	PCNA →	+0.221	+2.087	.007	.005	3	2
COAD	PAI-1 →	+0.865	+2.815	.007	.036	3	1
COAD	RAD51 →	+0.198	+2.815	.022	.036	2	2
COAD	SETD2 →	+0.516	+2.820	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by FBLN7 expression — UCEC

Explore this box plot interactively →