FBLN5

Across TCGA patient cohorts, FBLN5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBLN5-associated genes across cancer lineages are MEK1, 14-3-3_beta, and eIF4E. Each is linked with FBLN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBLN5-to-partner and partner-to-FBLN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FBLN5-low versus FBLN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN5→partner) and Y-score (partner→FBLN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.423	+2.662	.002	<.001	3	2
UCEC	14-3-3_beta →	-0.105	-1.752	.005	.014	3	1
UCEC	eIF4E →	+0.172	+1.765	.029	.014	3	1
UCEC	ACC1 →	+0.292	+1.750	.032	.049	3	1
UCEC	Heregulin →	-0.122	-1.700	.008	.042	3	1
UCEC	SF2 →	-0.115	-2.295	.004	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MEK1 by FBLN5 expression — UCEC

Explore this box plot interactively →