FBLN1

Across TCGA pan-cancer cohorts, FBLN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBLN1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FBLN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBLN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where FBLN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.508	0.862	.012	20	view →
HNSC	DFS	Median	All	0.856	0.708	.011	11	view →
PDAC	DFS	Quartile	III,IV	0.212	0.898	.002	11	view →
CCRCC	OS	Median	II,III,IV	0.327	0.917	.015	10	view →
GBM	OS	Median	All	0.292	0.502	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBLN1–LSCC (DFS)

Open the LSCC breakdown →