FBLN1

Across TCGA patient cohorts, FBLN1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBLN1-associated genes across cancer lineages are ATM, eIF4E, and FoxM1. Each is linked with FBLN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBLN1-to-partner and partner-to-FBLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FBLN1-low versus FBLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN1→partner) and Y-score (partner→FBLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.636	-2.584	<.001	<.001	3	4
UCEC	eIF4E →	+0.201	+3.598	.004	.001	3	3
UCEC	FoxM1 →	+0.170	+1.584	.049	.009	3	3
SKCM	CDK1 →	+0.182	+3.000	.023	.035	3	2
UCEC	eEF2 →	+0.248	+1.321	.038	.029	3	2
UCEC	ERK2 →	+0.153	+1.847	.017	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by FBLN1 expression — UCEC

Explore this box plot interactively →