FBLN1

Across TCGA cell cohorts, FBLN1 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible FBLN1-associated genes across cancer lineages are KRT25, LCE1C, and H2BW2. Each is linked with FBLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBLN1-to-partner and partner-to-FBLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT25 grouped by FBLN1-low versus FBLN1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN1→partner) and Y-score (partner→FBLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT25 →	+0.534	+3.841	<.001	.003	3	2
SKIN	LCE1C →	+0.120	+2.878	.001	.009	3	2
STOMACH	H2BW2 →	+0.165	+3.736	<.001	.006	3	2
STOMACH	FZD10 →	+0.298	+4.070	.005	.006	3	2
STOMACH	SPRR2G →	+0.096	+3.632	<.001	.009	3	2
STOMACH	TSGA13 →	+0.021	+3.632	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

KRT25 by FBLN1 expression — OVARY

Explore this box plot interactively →