FBL

Across TCGA pan-cancer cohorts, FBL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FBL data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FBL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FBL expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and LSCC are the cancer types where FBL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.921	.016	24	view →
LUAD	DFS	Median	All	0.761	0.440	.001	22	view →
LSCC	DFS	Median	All	0.874	0.728	.028	13	view →
CCRCC	DFS	Tertile	III,IV	0.346	0.665	.015	12	view →
GBM	OS	Quartile	All	0.495	0.278	.022	2	view →
PDAC	DFS	Median	All	0.432	0.272	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FBL–COAD (DFS)

Open the COAD breakdown →