FBL

Across TCGA patient cohorts, FBL mutation is significantly associated with the RNA expression of many other genes, with 1,345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBL-associated genes across cancer lineages are CENPV, SERHL, and FAM136A. Each is linked with FBL in more than 1 cancer types. Because this analysis shows association rather than direction, both FBL-to-partner and partner-to-FBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPV grouped by FBL-low versus FBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBL→partner) and Y-score (partner→FBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPV →	+0.963	+2.732	.004	.003	3	2
UCEC	SERHL →	+0.496	+3.330	.002	.005	3	2
UCEC	FAM136A →	+0.479	+3.387	.003	.004	3	2
UCEC	GP1BA →	+0.455	+3.370	<.001	.004	3	2
UCEC	LONP1 →	+0.634	+3.386	.001	.004	3	2
UCEC	POLH-AS1 →	+0.658	+3.353	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,345 associations by consensus.

CENPV by FBL expression — UCEC

Explore this box plot interactively →