FBL

Across TCGA patient cohorts, FBL mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBL-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Ku80. Each is linked with FBL in more than 1 cancer types. Because this analysis shows association rather than direction, both FBL-to-partner and partner-to-FBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FBL-low versus FBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBL→partner) and Y-score (partner→FBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.193	+2.584	.049	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-3.169	.029	.019	3	1
UCEC	Ku80 →	+0.263	+1.887	.016	.031	3	1
UCEC	PDCD4 →	-0.692	-2.584	.001	.011	3	1
UCEC	Rad50 →	-0.269	-2.584	.017	.011	3	1
UCEC	STAT3_pY705 →	-0.465	-3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by FBL expression — UCEC

Explore this box plot interactively →