FBL

Across TCGA cell cohorts, FBL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,298 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FBL-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, DNA-templated transcription termination, and Maturation of SSU-rRNA. Each is linked with FBL in more than 18 cancer types. Because this analysis shows association rather than direction, both FBL-to-partner and partner-to-FBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by FBL-low versus FBL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBL→partner) and Y-score (partner→FBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Nucleolar large rRNA transcription by RNA polymerase I →	+0.139	+1.224	<.001	<.001	3	19
BONE	DNA-templated transcription termination →	+0.127	+1.216	.001	.001	3	17
URINARY_TRACT	Maturation of SSU-rRNA →	+0.142	+1.677	<.001	<.001	3	16
BONE	U4 snRNA 3'-end processing →	+0.190	+1.144	.001	.002	3	16
URINARY_TRACT	Ribosome biogenesis →	+0.107	+1.358	<.001	<.001	3	16
PANCREAS	DNA replication initiation →	+0.154	+0.938	.002	.005	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,298 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by FBL expression — URINARY_TRACT

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