FBL

Across TCGA cell cohorts, FBL mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FBL-associated genes across cancer lineages are SPAG11B, OR1L3, and MBD3L2. Each is linked with FBL in more than 1 cancer types. Because this analysis shows association rather than direction, both FBL-to-partner and partner-to-FBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPAG11B grouped by FBL-low versus FBL-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBL→partner) and Y-score (partner→FBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPAG11B →	+0.143	+5.614	<.001	.002	3	1
LARGE_INTESTINE	OR1L3 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	MBD3L2 →	+0.119	+5.415	<.001	.004	3	1
LUNG_SCLC	CD40LG →	+0.019	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	BSX →	+0.162	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SPAG11B by FBL expression — PANCREAS

Explore this box plot interactively →