FBH1

Across TCGA pan-cancer cohorts, FBH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBH1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FBH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBH1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where FBH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.597	1.000	<.001	38	view →
CCRCC	OS	Median	All	1.000	0.655	.004	27	view →
LUAD	DFS	Tertile	III,IV	0.227	0.760	.006	19	view →
HNSC	OS	Median	All	0.912	0.800	.010	14	view →
PDAC	DFS	Median	IV	0.203	0.785	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBH1–LSCC (DFS)

Open the LSCC breakdown →