FBH1

Across TCGA patient cohorts, FBH1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBH1-associated genes across cancer lineages are ASNS, STAT3_pY705, and MEK1. Each is linked with FBH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBH1-to-partner and partner-to-FBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FBH1-low versus FBH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBH1→partner) and Y-score (partner→FBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.460	+1.925	<.001	.004	3	4
UCEC	STAT3_pY705 →	-0.290	-1.662	<.001	.009	3	3
UCEC	MEK1 →	+0.370	+2.392	.001	<.001	3	3
UCEC	4E-BP1 →	+0.439	+2.432	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.444	+3.178	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.077	-1.558	.015	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ASNS by FBH1 expression — UCEC

Explore this box plot interactively →