FBH1

Across TCGA cell cohorts, FBH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,385 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBH1-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Regulation of cilium assembly, and Negative regulation of telomere capping. Each is linked with FBH1 in more than 10 cancer types. Because this analysis shows association rather than direction, both FBH1-to-partner and partner-to-FBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by FBH1-low versus FBH1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBH1→partner) and Y-score (partner→FBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.087	+0.615	<.001	<.001	3	11
BLOOD_Lymphoma	Regulation of cilium assembly →	+0.043	+0.621	<.001	<.001	3	10
SOFT_TISSUE	Negative regulation of telomere capping →	+0.070	+0.344	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.055	+1.031	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of smoothened signaling pathway →	+0.046	+1.066	<.001	<.001	3	9
URINARY_TRACT	Regulation of epinephrine secretion →	+1.375	+0.532	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,385 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by FBH1 expression — LUNG_SCLC

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