Across TCGA patient cohorts, FBF1 mutation is significantly associated with the RNA expression of many other genes, with 1,561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBF1-associated genes across cancer lineages are PGAM5, DNM2, and TIMM44. Each is linked with FBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBF1-to-partner and partner-to-FBF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBF1→partner) and Y-score (partner→FBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5 →	+0.594	+2.807	<.001	<.001	3	3
UCEC	DNM2 →	+0.368	+3.470	.005	<.001	3	3
UCEC	TIMM44 →	+0.316	+3.369	.006	.005	3	3
SKCM	RRP9 →	+0.537	+3.651	<.001	.001	3	3
UCEC	LONP1 →	+0.598	+3.839	<.001	<.001	3	3
SKCM	RAD23A →	+0.429	+3.603	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,561 associations by consensus.

Exploration

FBF1 survival (RNA) · tumor vs normal (RNA) · all FBF1 data types