Across TCGA patient cohorts, FBF1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBF1-associated genes across cancer lineages are PAI-1, MSH2, and PDK1. Each is linked with FBF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBF1-to-partner and partner-to-FBF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBF1→partner) and Y-score (partner→FBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PAI-1 →	+1.163	+2.824	<.001	.034	3	2
UCEC	MSH2 →	-0.294	-3.143	.002	.018	3	2
UCEC	PDK1 →	+0.104	+2.820	.023	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+1.304	+3.827	<.001	<.001	3	2
SKCM	EGFR_pY1173 →	+0.145	+3.000	.002	.034	3	1
SKCM	MIG-6 →	+0.174	+3.025	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

FBF1 survival (RNA) · tumor vs normal (RNA) · all FBF1 data types