FAXC

Across TCGA cell cohorts, FAXC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,609 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAXC-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Regulation of sister chromatid segregation, and Negative regulation of metaphase/anaphase transition of cell cycle. Each is linked with FAXC in more than 10 cancer types. Because this analysis shows association rather than direction, both FAXC-to-partner and partner-to-FAXC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by FAXC-low versus FAXC-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAXC→partner) and Y-score (partner→FAXC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.128	+2.118	.001	<.001	2	11
URINARY_TRACT	Regulation of sister chromatid segregation →	+0.119	+1.962	.001	<.001	2	11
STOMACH	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.151	+2.377	.001	<.001	3	9
STOMACH	Negative regulation of chromosome separation →	+0.151	+2.377	.001	<.001	3	9
URINARY_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.076	+1.734	<.001	.008	3	9
BLOOD_Lymphoma	Purine ribonucleotide biosynthetic process →	+0.059	+1.506	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,609 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by FAXC expression — URINARY_TRACT

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