FATE1

Across TCGA pan-cancer cohorts, FATE1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FATE1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher FATE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FATE1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC, COAD, and BLCA are the cancer types where FATE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.155	0.766	<.001	45	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
BLCA	OS	Median	All	0.174	0.720	<.001	12	view →
SKCM	OS	Median	All	0.755	0.321	.007	12	view →
ACC	OS	Median	All	0.273	0.818	.031	9	view →
HNSC	OS	Median	All	0.166	0.710	.003	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	All	0.112	0.360	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FATE1–LUSC (OS)

Open the LUSC breakdown →