FATE1

Across TCGA patient cohorts, FATE1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FATE1-associated genes across cancer lineages are eIF4G, ER-alpha, and FASN. Each is linked with FATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FATE1-to-partner and partner-to-FATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by FATE1-low versus FATE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FATE1→partner) and Y-score (partner→FATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.314	+3.700	.029	.001	3	1
UCEC	ER-alpha →	-0.846	-3.000	.027	.036	3	1
UCEC	FASN →	+0.443	+2.584	.015	.011	3	1
UCEC	FoxM1 →	+0.309	+3.700	.010	.001	3	1
UCEC	ACC1 →	+0.456	+3.321	.007	.010	3	1
UCEC	MEK1 →	+0.399	+3.321	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4G by FATE1 expression — UCEC

Explore this box plot interactively →