Across TCGA patient cohorts, FAT4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,011 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FAT4-associated genes across cancer lineages are AOC3, DIPK2B, and MFAP4. Each is linked with FAT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FAT4-to-partner and partner-to-FAT4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT4→partner) and Y-score (partner→FAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AOC3 →	+0.970	+0.339	<.001	<.001	3	4
OV	DIPK2B →	+0.804	+0.476	.001	<.001	3	4
LUAD	MFAP4 →	+1.317	+0.343	<.001	<.001	3	4
HNSC	RCAN2 →	+0.909	+0.524	<.001	<.001	3	4
LSCC	PODN →	+0.869	+0.302	<.001	<.001	3	4
OV	LHFPL6 →	+1.007	+0.383	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,011 associations by consensus.

Exploration

FAT4 survival (RNA) · tumor vs normal (RNA) · all FAT4 data types