Across TCGA patient cohorts, FAT4 mutation is significantly associated with the total protein of many other genes, with 119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAT4-associated genes across cancer lineages are ASNS, 4E-BP1, and Caveolin-1. Each is linked with FAT4 in more than 7 cancer types. Because this analysis shows association rather than direction, both FAT4-to-partner and partner-to-FAT4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT4→partner) and Y-score (partner→FAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.344	+1.716	.001	.001	3	8
STAD	4E-BP1 →	+0.306	+1.710	<.001	<.001	3	7
CESC	Caveolin-1 →	-0.778	-2.459	.005	.017	3	6
STAD	FASN →	+0.399	+3.169	<.001	<.001	3	6
COAD	Caspase-7-cleavedD198 →	+0.806	+1.753	<.001	<.001	3	6
COAD	JNK_pT183_Y185 →	-0.111	-0.830	.041	.049	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

Exploration

FAT4 survival (RNA) · tumor vs normal (RNA) · all FAT4 data types