Across TCGA cell cohorts, FAT4 mutation is significantly associated with the RNA expression of many other genes, with 2,494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAT4-associated genes across cancer lineages are COPS4, MSH4, and SIGIRR. Each is linked with FAT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FAT4-to-partner and partner-to-FAT4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT4→partner) and Y-score (partner→FAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COPS4 →	+0.652	+1.502	<.001	<.001	3	4
LARGE_INTESTINE	MSH4 →	+0.233	+1.657	<.001	<.001	3	4
STOMACH	SIGIRR →	+0.949	+2.070	.002	.003	3	4
LARGE_INTESTINE	UBE2D3 →	+0.435	+1.502	<.001	<.001	3	4
LARGE_INTESTINE	B3GNT4 →	+0.778	+1.588	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.987	+1.759	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

Exploration

FAT4 survival (RNA) · tumor vs normal (RNA) · all FAT4 data types