FAT3

Across TCGA pan-cancer cohorts, FAT3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated FAT3 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FAT3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAT3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

BLCA, UVM, and ESCA are the cancer types where FAT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	IV	0.225	0.502	.001	36	view →
UVM	DFS	Median	All	0.032	0.762	<.001	30	view →
ESCA	OS	Median	All	0.207	0.955	<.001	30	view →
ACC	DFS	Median	II,III,IV	0.050	0.595	<.001	25	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
CESC	OS	Median	III,IV	0.151	0.669	.005	12	view →
SKCM	DFS	Median	IV	0.835	0.221	.024	11	view →
UCEC	DFS	Median	All	0.762	0.609	.036	4	view →
DLBC	OS	Median	All	0.613	0.945	.049	3	view →
HNSC	OS	Median	All	0.917	0.755	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

FAT3–BLCA (DFS)

Open the BLCA breakdown →