FAT2

Across TCGA pan-cancer cohorts, FAT2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAT2 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FAT2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FAT2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC and LSCC are the cancer types where FAT2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.219	0.659	.009	10	view →
LSCC	DFS	Median	II,III,IV	0.990	0.856	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAT2–PDAC (OS)

Open the PDAC breakdown →