FAT1

Across TCGA pan-cancer cohorts, FAT1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAT1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FAT1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAT1 is over-expressed in tumor.

PDAC, COAD, and LSCC are the cancer types where FAT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+0.669	<.001	10	view →
COAD	Female	III,IV	+0.561	<.001	10	view →
LSCC	Female	All	+0.411	<.001	9	view →
HNSC	Male	III,IV	+0.698	<.001	8	view →
LUAD	Male	All	+0.185	.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAT1–PDAC

Open the PDAC breakdown →