Across TCGA patient cohorts, FASTKD5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASTKD5-associated genes across cancer lineages are MEK1, Notch1, and Caspase-7-cleavedD198. Each is linked with FASTKD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FASTKD5-to-partner and partner-to-FASTKD5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTKD5→partner) and Y-score (partner→FASTKD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.272	+1.700	.039	.042	3	2
UCEC	Notch1 →	+0.160	+1.584	.001	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.715	+2.242	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.220	-2.000	.015	.029	3	1
UCEC	A-Raf_pS299 →	-0.096	-1.874	.026	.049	3	1
UCEC	INPP4B →	-0.233	-2.459	.045	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

FASTKD5 survival (RNA) · tumor vs normal (RNA) · all FASTKD5 data types