FASTKD2

Across TCGA patient cohorts, FASTKD2 mutation is significantly associated with the RNA expression of many other genes, with 4,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASTKD2-associated genes across cancer lineages are SNORD3P1, RNU6-36P, and SNRPD3. Each is linked with FASTKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FASTKD2-to-partner and partner-to-FASTKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD3P1 grouped by FASTKD2-low versus FASTKD2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTKD2→partner) and Y-score (partner→FASTKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORD3P1 →	+0.247	+5.182	<.001	.007	3	2
LIHC	RNU6-36P →	+0.396	+4.233	<.001	.003	3	2
UCEC	SNRPD3 →	+0.400	+2.201	<.001	<.001	3	2
UCEC	CCDC134 →	+0.584	+4.119	<.001	<.001	3	2
UCEC	TXN2 →	+0.434	+2.298	<.001	<.001	3	2
UCEC	RANGAP1 →	+0.475	+2.567	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

SNORD3P1 by FASTKD2 expression — HNSC

Explore this box plot interactively →