FASTKD2

Across TCGA patient cohorts, FASTKD2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASTKD2-associated genes across cancer lineages are FoxM1, STAT3_pY705, and ATM. Each is linked with FASTKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FASTKD2-to-partner and partner-to-FASTKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FASTKD2-low versus FASTKD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTKD2→partner) and Y-score (partner→FASTKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.267	+2.807	.004	<.001	3	2
UCEC	STAT3_pY705 →	-0.398	-2.405	<.001	.003	3	2
UCEC	ATM →	-0.656	-3.794	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.505	+1.604	.018	.041	3	2
UCEC	4E-BP1 →	+0.258	+2.252	.008	.005	3	2
UCEC	Cyclin-B1 →	+0.685	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FoxM1 by FASTKD2 expression — UCEC

Explore this box plot interactively →