FASN

Across TCGA patient cohorts, FASN mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASN-associated genes across cancer lineages are Cyclin-E2, Lck, and JNK2. Each is linked with FASN in more than 3 cancer types. Because this analysis shows association rather than direction, both FASN-to-partner and partner-to-FASN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by FASN-low versus FASN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASN→partner) and Y-score (partner→FASN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.163	+1.899	.047	.028	3	4
STAD	Lck →	+0.528	+2.828	<.001	.033	3	3
UCEC	JNK2 →	+0.242	+2.763	<.001	<.001	3	3
UCEC	ATM →	-0.547	-2.209	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.285	+1.459	<.001	.001	3	3
UCEC	eEF2 →	+0.286	+2.087	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Cyclin-E2 by FASN expression — COAD

Explore this box plot interactively →