FASN

Across TCGA cell cohorts, FASN mutation is significantly associated with the RNA expression of many other genes, with 1,766 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FASN-associated genes across cancer lineages are VPS37D, TATDN3, and DBR1. Each is linked with FASN in more than 2 cancer types. Because this analysis shows association rather than direction, both FASN-to-partner and partner-to-FASN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VPS37D grouped by FASN-low versus FASN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASN→partner) and Y-score (partner→FASN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VPS37D →	+0.671	+2.744	<.001	.001	3	3
BLOOD_Leukemia	TATDN3 →	+0.431	+2.553	.004	.006	3	3
LARGE_INTESTINE	DBR1 →	+0.470	+2.629	<.001	.001	3	3
LARGE_INTESTINE	TOM1L1 →	+0.515	+1.628	.004	.002	3	3
LARGE_INTESTINE	CCNB3 →	+0.496	+1.628	<.001	.002	3	3
LARGE_INTESTINE	CATSPER3 →	+0.353	+1.628	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,766 associations by consensus.

VPS37D by FASN expression — BLOOD_Leukemia

Explore this box plot interactively →