FAS

Across TCGA pan-cancer cohorts, FAS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAS data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FAS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAS expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, GBM, and HNSC are the cancer types where FAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.549	0.251	<.001	72	view →
GBM	DFS	Quartile	All	0.264	0.569	<.001	16	view →
HNSC	OS	Median	All	0.957	1.000	.017	4	view →
UCEC	OS	Median	All	0.991	0.911	.035	4	view →
LUAD	DFS	Tertile	All	0.640	0.347	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAS–PDAC (DFS)

Open the PDAC breakdown →