FAS

Across TCGA patient cohorts, FAS mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAS-associated genes across cancer lineages are ERK2, PDCD4, and TIGAR. Each is linked with FAS in more than 1 cancer types. Because this analysis shows association rather than direction, both FAS-to-partner and partner-to-FAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FAS-low versus FAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAS→partner) and Y-score (partner→FAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.143	+1.807	.039	.025	3	2
UCEC	PDCD4 →	-0.619	-1.896	<.001	.015	3	2
UCEC	TIGAR →	+0.154	+1.306	.005	.036	3	2
UCEC	ATM →	-0.572	-2.321	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.181	-1.700	.045	.042	3	1
UCEC	eIF4E →	+0.173	+3.335	.022	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ERK2 by FAS expression — UCEC

Explore this box plot interactively →